eng
National Information and Documentation Center (NIDOC), Academy of Scientific Research and Technology
Egyptian Journal of Biomedical Engineering and Biophysics
1110-8525
2357-0911
2018-12-01
19
1
1
11
10.21608/ejbbe.2018.3208.1016
14445
Original Article
The Dielectric Study of Calcium Hydroxylapatite Doped by Magnesium Ions
Moustafa Ibrahim
mustafa.ibrahim@fsc.bu.edu.eg
1
Samira Sallam
samira.salam@fsc.bu.edu.eg
2
Egypt, Benha University, faculty of science, physics, biophysics
Physics dept, Faculty of Science Benha University
Hydroxyapatite is considered as one of the most effective biomaterials with general formula Ca10 [PO4]6[0H] 2 , many substances have been used for doping hydroxypatite like F, Mg, CO3, Zn, Bi and Na ,to improve the properties of the HA crystal . In this paper, we discuss the influence of magnesium ions on the electrical properties of the HA crystal . HA (S1) and Mg loaded hydroxy apatite (S2,S3 and S4) of different magnesium concentrations have been prepared by wet precipitation method. The dielectric parameters (ε' ) and (ε'') measured at different temperature, relaxation time of relaxation process was calculated from the cole cole plot . The advantages of modulus studies were to recognize the conduction process and study the effect on the frequency and estimate the relaxation frequency. Conduction mechanism has been studied using alternating current measurements, analyzing their dependence on temperature and frequency. The exponent (S) was estimated to recognize the type of conduction. The activation energy studied also to confirm the conductivity measurements . The electrical measurements confirmed that as the addition of Mg increased , the conductivity of the substance would increase and this will improve the bioactivity of HA .
https://ejbbe.journals.ekb.eg/article_14445_6df1fdba3d121b25f8c77c91f261b86c.pdf
Hydroxyapatite
Magnesium
Conductivity
eng
National Information and Documentation Center (NIDOC), Academy of Scientific Research and Technology
Egyptian Journal of Biomedical Engineering and Biophysics
1110-8525
2357-0911
2018-12-01
19
1
45
50
10.21608/ejbbe.2018.4703.1021
20535
Original Article
Nano-rods oxide materials for biosensor application.
Hanan Abdelwahab
norallah111@yahoo.com
1
Inas Battisha
szbasha@yahoo.com
2
Aziza Elseid
azelsaeid@yahoo.com
3
Ayda Salama
salama.aida@yahoo.com
4
physics department- national research center, dokii- egypt
physics department- national research center
physics department- al- azhar university (girls)- faculty of science
Physics Dpt., faculty of science (girls), Al azhar University
Iron ions selective biosensor (Fe3+) based on zinc oxide nano-rods thin film symbolic as ZnO-(NRs)TF will be developed and prepared. The potentiometric response for ZnO-(NRs)TF deposited on conducting plastic and silicon substrates as working electrode versus reference electrode (Ag/AgCl) was found to be linear against logarithmic FeCl3 with concentration range between 10-6 M and 10-2 M. The ZnO-(NRs)TF will be grown on conducting plastic and silicon substrates using two methods (Sol - Gel and aqueous chemical growth (ACG)) by seed layers and nano-rod growth will be investigated. For fabricate an advanced extracellular iron biosensor, the ZnO-(NRs) on plastic and silicon substrates were coated with a thin layer of specific ionophore membrane to be used for iron concentration measurements in extracellular solution. The prepared sample crystallinity and microstructure will be characterized by x-ray diffraction (XRD) which, imply that ZnO-(NRs)TF sample crystallite sizes are in the nano-scale. The prepared samples morphology was characterized by Field emission scanning electron microscope (FESEM).
https://ejbbe.journals.ekb.eg/article_20535_cabb19981477fed177ec6b1f5c0f5af4.pdf
ZnO-(NRs)TF
Sol gel
aqueous chemical growth
XRD
FESEM and biosensor
eng
National Information and Documentation Center (NIDOC), Academy of Scientific Research and Technology
Egyptian Journal of Biomedical Engineering and Biophysics
1110-8525
2357-0911
2018-05-22
19
1
13
24
10.21608/ejbbe.2018.3301.1017
7434
Original Article
The Role of Liposome -Encapsulated Ascorbic Acid on Hemoglobin Damage by Gamma Irraidation.
Basma El adawy
basmajoe2012@yahoo.com
1
AIDA Salama
aida@yahoo.com
2
Mohamed Hassaneen Gaber
liposome32@hotmail.com
3
Aziza El saeid
aziza@yahoo.com
4
Al-Azhar University Faculty of Science Girls Branch Department of Physics
Physics Department, Faculty of Science, Al azhar University
Biophysics Dpt., Faculty of Science , Cairo University
Physics Department, Faculty of Science, Al azhar University
Ionizing radiation causes serious damage in a biological system. Some drugs and antioxidants are used to prevent such damage. In vitro we study the effect of free ascorbic acid(AA) and liposome encapsulation ascorbic acid (LEAA) to prevent damage induced by gamma irridiatin on rats blood . Liposomes prepared by thin film hydration method . Size ,and poly dispersed index (PDI) were analyzed by dynamic light scattering before and after encapsulation AA ,and shape was analyzed by transmission electron microscopy(TEM). Percentage encapsulation efficiency (EE%) of ascorbic acid was determined and IR study has been employed to reveal structure alteration in vesicles before and after encapsulation. two doses of free ascorbic acid ( 20 µg /ml ,40 µg /ml) were selected to be used for such purpose. Also the same doses were used encapsulated in liposomes . Our study were carried through UV-visible spectrum absorption spectrum , relative viscosity and conductivity measurement . The results show that EE% have a high encapsulation of vitamins C, there no detectable change is observed in size of liposome before and after encapsulation. The data obtained from UV-visible indicate that there is great change in the absorbance of sort band, and in the absorption A576/ A541 ratio in blood irradiated to 5 GY γ- irradiation by dose rate 62cGY/mint as compared with normal hemoglobin. The result indicated that ,the change decreases by increasing doses of free AA came close to normal hemoglobin and approaching more to normal in the case of liposome encapsulation ascorbic acid .
https://ejbbe.journals.ekb.eg/article_7434_33b1248d816120014eedc0a6d617d8af.pdf
liposome
Hemoglobin
γ-irradiation
ascorbic acid
UV visible absorption spectra
eng
National Information and Documentation Center (NIDOC), Academy of Scientific Research and Technology
Egyptian Journal of Biomedical Engineering and Biophysics
1110-8525
2357-0911
2018-12-01
19
1
25
31
10.21608/ejbbe.2018.3319.1018
7435
Original Article
Biophysical Studies on the Effect of Gamma Rays on Liposomes
SAID TAHA
saidataha@hotmail.com
1
Ahmed Abdelrahman
ahmedbiohysics2013@gmail.com
2
Raed El shazly
r.shazly@gmail.com
3
Mohamed hassaneen Gaber
liposome32@hotmail.com
4
Amr Kany
amrkany@yahoo.com
5
FACULTY OF SCIENCE- CAIRO UNIVERSITY
department of physics, faculty of science, Al azhar university, Cairo, Egypt
Physics department , Faculty of science, Al azhar University
Biophysics Dpt., Faculty of Science , Cairo University
Physics department, Faculty of Science , AlAzhar University
Liposomes are vesicular structures made of lipids that are formed in aqueous solutions, which can be used as models to study the cell membrane. In the present study the effects of gamma (γ) rays on dipalmitoylphosphatidylcholine (DPPC) liposomes were studied by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, as well as dynamic light scattering (DLS) and viscosity measurements. The DPPC liposomes were exposed to three different doses 40, 80, and 120Gy which emitted from 60Co gamma rays source with a dose rate of 9 kGy/h. The DLS measurements confirmed the monodispersity of all samples. TEM results revealed that there is a change in morphology and size of liposomes, which is in a good agreement with the increase in viscosity measurements. FTIR measurements showed significant changes in the characteristics bands of DPPC liposomes confirming the effect of γ-rays on the main groups such as CH2 bending vibrations and the symmetric and antisymmetric PO2- stretching vibrations at 1090 and 1220 cm-1 respectively. In addition to the shifting of the OH stretching vibrations from 3439 cm-1 to 3453 cm-1due to the 120 Gy exposure. The spectral changes seem to be due to some sort of water loss and molecular conformational changes due to ionization and formation of free radicals which affect the head groups of the DPPC liposomes leading to lipid lateral diffusion enhancing the fusion of small vesicles to form larger structures.
https://ejbbe.journals.ekb.eg/article_7435_172135828767444f54e2940dc062356e.pdf
liposomes
DPPC
Gamma rays
Characterization
eng
National Information and Documentation Center (NIDOC), Academy of Scientific Research and Technology
Egyptian Journal of Biomedical Engineering and Biophysics
1110-8525
2357-0911
2018-12-01
19
1
33
44
10.21608/ejbbe.2018.3898.1019
19571
Original Article
Molecular Structure Changes Of Rat’s Retina After Sodium Iodate Injection and The Effect Of Taurine
M.I. El Gohary
1
E.M. Aly
2
A.E. Malash
ahmedmalash71@yahoo.com
3
1,3 Physics Department, Biophysics Branch, Faculty of Science, Al-Azhar University (Boys)
Biophysics&Laser Science Unit, Research Institute of Ophthalmology,
Physics Department, Biophysics Branch, Faculty of Science, Al-Azhar University (Boys), Cairo
The aim of present work is to investigate the mechanism of action of sodium iodate (NaIO3) on the molecular structure of retina and whether the nutritional intake of taurine may delay the development of age macular degeneration (AMD) disease induced by NaIO3 using Fourier transform infrared spectroscopy (FTIR). One hundred and five rats (200-230 g) are classified into three groups. I (15 rats) used as control, II (45 rats) received a single intravenous injection of 25, 50, or 75 mg/kg NaIO3, and III (45 rats) supplemented with 4 g taurine /100 g diet for two weeks before injection of NaIO3. The injection continued until decapitation. All injected doses of NaIO3 are associated with vibrational changes that include decrement of the modes of vibration related to stretching OH and amide II, significant increases (p˂0.05) in wavenumber and width of asymmetrical OH and disappear of asymmetrical NH3. Also, there are significant diminish (p˂0.05) in α-helix content in the same context, in addition to significant increments (p˂0.05) in β-Sheet indicating the conformational changes of the secondary structure of protein due to NaIO3 injection. Enhancement of most changes that previously detected in FTIR spectra are noticed after taurine treatment especially before and after low dose of NaIO3. NaIO3 is considered to be specific for animal model as age macular degeneration. Taurine action is efficient as antioxidant to protect retina from oxidative stress limits in range of 25 mg of NaIO3 and decreases the efficiency by increasing the dose of NaIO3 up to 75 mg.
https://ejbbe.journals.ekb.eg/article_19571_a4335b321b11f0526bee2f30edc3955d.pdf
Key Words: Age macular degeneration (AMD)
retina
FTIR
antioxidant
eng
National Information and Documentation Center (NIDOC), Academy of Scientific Research and Technology
Egyptian Journal of Biomedical Engineering and Biophysics
1110-8525
2357-0911
2018-12-01
19
1
51
61
10.21608/ejbbe.2019.5193.1022
26070
Original Article
Magnetic Properties and Induction Heating Ability Studies of Spinal Ferrite Nanoparticles for Hyperthermia Treatment of Tumours”
Diaa EL-Rahman Rayan
diaa001@yahoo.com
1
Mahmoud Ismail
m10m10e10@gmail.com
2
Central Metallurgical Research & Development Institute (CMRDI)
physics department, faculty of science, AL Azhar university, Cairo, Egypt
Abstract In this research synthesizes nanocrystalline CuFe2O4 spinel structure using co-precipitation method. X-ray diffraction (XRD), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM) are utilized in order to study crystalline size, lattice parameters, microstructure and optical and magnetic properties of the formed nanopowders. Moreover, the induction heating behavior of the formed nanopowders with alternative magnetic field was also determined based on the change of specific absorption rate (SAR) or specific loss power (SLP) with the synthesis conditions. Indeed, heating properties of the CuFe2O4 nanoparticles in an alternating magnetic field at 150-300 kHz were estimated. The specific heat rate SAR values were in the range from 125 to 350 W/g. Finally, large SAR values are obtained using low magnetic field, making Cu ferrite appropriate for hyperthermia treatment of cancer. These results will help us to apply to complete in this trend of tumor treatment. Keywords: CuFe2O4; Spinel Ferrites; Optical properties; Magnetic Properties, Induction Heating, Specific Heat Rate SAR.
https://ejbbe.journals.ekb.eg/article_26070_7f08a010a9af27e10b667945e0de3b16.pdf
Keywords: CuFe2O4
Spinel Ferrites
, Induction Heating, Specific Heat Rate SAR